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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731835
Species: Mus musculus
RGD Object: Gene
Symbol: Ggt1
Name: gamma-glutamyltransferase 1
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ggt1decreases expressionISOGgt1 (Rattus norvegicus)6480464CTDThioacetamide results in decreased expression of GGT1 mRNAPMID:19784758
Ggt1increases activityISOGgt1 (Rattus norvegicus)6480464CTDThioacetamide results in increased activity of GGT1 proteinPMID:22899499
Ggt1increases expressionISOGgt1 (Rattus norvegicus)6480464CTDThioacetamide results in increased expression of GGT1 mRNA; Thioacetamide results in increased expression of GGT1 proteinPMID:23411599 PMID:24704557
Ggt1multiple interactionsISOGgt1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GGT1 mRNA; Coffee inhibits the reaction [Thioacetamide results in increased activity of GGT1 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]; silybin-phytosome inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]PMID:22899499 PMID:24704557 PMID:28943392
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