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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731821
Species: Mus musculus
RGD Object: Gene
Symbol: Cdh2
Name: cadherin 2
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh2decreases expressionEXP 6480464CTDthymoquinone results in decreased expression of CDH2 proteinPMID:32112862
Cdh2decreases expressionISOCDH2 (Homo sapiens)6480464CTDthymoquinone results in decreased expression of CDH2 proteinPMID:32112862 PMID:35774120
Cdh2multiple interactionsISOCDH2 (Homo sapiens)6480464CTDCTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of CDH2 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of CDH2 protein]PMID:32112862 PMID:35774120
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