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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731784
Species: Homo sapiens
RGD Object: Gene
Symbol: GRIN1
Name: glutamate ionotropic receptor NMDA type subunit 1
Acc ID: CHEBI:50103
Term: excitatory amino acid agonist
Definition: An agent that binds to and activates excitatory amino acid receptors.
Chemical ID: MESH:D018690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GRIN1multiple interactionsEXP 6480464CTD[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists; [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Excitatory Amino Acid Agonists; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]; Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]; Urethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]PMID:11812690 PMID:19224577
GRIN1multiple interactionsISOGrin1 (Mus musculus)6480464CTD[[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid AgonistsPMID:19285052
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