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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731752
Species: Mus musculus
RGD Object: Gene
Symbol: Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc5a5affects localizationISOSLC5A5 (Homo sapiens)6480464CTDTretinoin affects the localization of SLC5A5 proteinPMID:16439463
Slc5a5decreases expressionISOSLC5A5 (Homo sapiens)6480464CTDTretinoin results in decreased expression of SLC5A5 mRNAPMID:21924320
Slc5a5increases expressionISOSLC5A5 (Homo sapiens)6480464CTDTretinoin results in increased expression of SLC5A5 mRNA; Tretinoin results in increased expression of SLC5A5 proteinPMID:16234306 PMID:16439463 PMID:16954431 PMID:17045167 PMID:17332617 PMID:20300827
Slc5a5multiple interactionsISOSLC5A5 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine promotes the reaction [[Tretinoin co-treated with Hydrocortisone] affects the localization of SLC5A5 protein]; 1-Methyl-3-isobutylxanthine promotes the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased expression of SLC5A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]]; [decitabine co-treated with Tretinoin] results in increased expression of SLC5A5 mRNA; [Dexamethasone co-treated with Tretinoin] results in increased expression of SLC5A5 mRNA; [troglitazone co-treated with Tretinoin] results in increased expression of SLC5A5 mRNA; Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 mRNA]; Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]; Colforsin inhibits the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased activity of SLC5A5 protein]; Dexamethasone promotes the reaction [Tretinoin results in increased expression of and results in increased activity of SLC5A5 protein]; Dexamethasone promotes the reaction [Tretinoin results in increased expression of SLC5A5 mRNA]; ESR1 protein promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]; Hydrocortisone promotes the reaction [Tretinoin affects the localization of SLC5A5 protein]; Hydrocortisone promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]; Tretinoin inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein]; Tretinoin results in increased expression of and results in increased activity of SLC5A5 protein; wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]]PMID:16234306 PMID:16439463 PMID:16730657 PMID:16954431 PMID:19524134 PMID:20300827
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