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GENE - TERM ANNOTATION REPORT

RGD ID: 731746
Species: Homo sapiens
RGD Object: Gene
Symbol: PTPN11
Name: protein tyrosine phosphatase non-receptor type 11
Acc ID: DOID:3069
Term: malignant astrocytoma
Definition: A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Astrocytoma "DO" "DO", http://www.cancer.org/Cancer/BrainCNSTumorsinAdults/DetailedGuide/brain-and-spinal-cord-tumors-in-adults-what-are-brain-spinal-tumors "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTPN11 EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:23817572
PTPN11 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Astrocytic tumorPMID:15985475 PMID:18470943 PMID:20186801 PMID:22781091 PMID:23624134 PMID:25741868 PMID:28492532 PMID:28650561 PMID:30311386 PMID:32737134
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