GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp1 | affects localization | EXP | | 6480464 | CTD | Cholesterol analog affects the localization of CASP1 protein | PMID:28633109 | Casp1 | increases activity | EXP | | 6480464 | CTD | Cholesterol analog results in increased activity of CASP1 protein | PMID:28633109 | Casp1 | increases cleavage | EXP | | 6480464 | CTD | Cholesterol results in increased cleavage of CASP1 protein | PMID:33239236 | Casp1 | multiple interactions | EXP | | 6480464 | CTD | Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]; bisphenol A promotes the reaction [Cholesterol results in increased cleavage of CASP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]; NBN protein inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased cleavage of CASP1 protein]]; SMPD1 protein affects the reaction [Cholesterol analog affects the localization of CASP1 protein]; SMPD1 protein affects the reaction [Cholesterol analog results in increased activity of CASP1 protein]; tempol inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]; Verapamil inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] | PMID:28633109 PMID:33239236 | Casp1 | increases expression | ISO | Casp1 (Rattus norvegicus) | 6480464 | CTD | Cholesterol analog results in increased expression of CASP1 mRNA | PMID:19477266 | Casp1 | multiple interactions | ISO | Casp1 (Rattus norvegicus) | 6480464 | CTD | [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein] | PMID:25833014 | | ||||||||||||||||||||||
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