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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731712
Species: Homo sapiens
RGD Object: Gene
Symbol: RB1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RB1decreases phosphorylationEXP 6480464CTDSirolimus results in decreased phosphorylation of RB1 proteinPMID:12393642 PMID:12565877 PMID:15753396 PMID:17121904 PMID:21528311 PMID:8419408
RB1multiple interactionsEXP 6480464CTD[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]; [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein; [Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; [tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]PMID:10373522 PMID:14979923 PMID:15778701 PMID:17121904 PMID:17700525 PMID:20054642
RB1decreases phosphorylationISORb1 (Rattus norvegicus)6480464CTDSirolimus results in decreased phosphorylation of RB1 proteinPMID:7532117
RB1multiple interactionsISORb1 (Mus musculus)6480464CTD[Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; Sirolimus inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]PMID:10849422 PMID:12417722 PMID:14979923
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