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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731712
Species: Homo sapiens
RGD Object: Gene
Symbol: RB1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RB1decreases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in decreased phosphorylation of RB1 proteinPMID:15157999 PMID:15322241 PMID:9705214
RB1multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[AHR protein binds to CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of RB1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased phosphorylation of RB1 protein]PMID:15157999 PMID:19917880 PMID:9705214
RB1affects expressionISORb1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of RB1 mRNAPMID:21570461
RB1decreases expressionISORb1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of RB1 mRNAPMID:21215274 PMID:34747641
RB1decreases phosphorylationISORb1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased phosphorylation of RB1 proteinPMID:24013123
RB1increases expressionISORb1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of RB1 mRNAPMID:12167310
RB1increases expressionISORb1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of RB1 mRNAPMID:32109520
RB1multiple interactionsISORb1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased phosphorylation of RB1 protein; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RB1 mRNAPMID:17942748 PMID:20637255
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