GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NPR3 | affects methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene affects the methylation of NPR3 3' UTR | PMID:27901495 | NPR3 | decreases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of NPR3 mRNA | PMID:35870112 | NPR3 | increases methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of NPR3 5' UTR; Benzo(a)pyrene results in increased methylation of NPR3 exon; Benzo(a)pyrene results in increased methylation of NPR3 promoter | PMID:27901495 | NPR3 | decreases expression | ISO | Npr3 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene metabolite results in decreased expression of NPR3 mRNA; Benzo(a)pyrene results in decreased expression of NPR3 mRNA | PMID:22228805 PMID:32553695 | NPR3 | decreases methylation | ISO | Npr3 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of NPR3 intron | PMID:27901495 | NPR3 | increases expression | ISO | Npr3 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of NPR3 mRNA | PMID:15034205 PMID:21569818 PMID:22610609 | NPR3 | multiple interactions | ISO | Npr3 (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NPR3 mRNA; AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NPR3 mRNA] | PMID:15034205 PMID:27858113 | |
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