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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731571
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1baffects response to substanceEXP 6480464CTDTNFRSF1B protein affects the susceptibility to DoxorubicinPMID:16618758
Tnfrsf1bmultiple interactionsEXP 6480464CTDTNFRSF1B protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA]; TNFRSF1B protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein]; TNFRSF1B protein affects the reaction [Doxorubicin results in decreased expression of FAS protein]PMID:16505099 PMID:16618758
Tnfrsf1bdecreases expressionISOTNFRSF1B (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of TNFRSF1B mRNAPMID:29803840
Tnfrsf1bdecreases expressionISOTnfrsf1b (Rattus norvegicus)6480464CTDDoxorubicin results in decreased expression of TNFRSF1B proteinPMID:17651020
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