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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731551
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLMincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of GCLM mRNA; Cadmium Chloride results in increased expression of GCLM proteinPMID:25596134 PMID:26365678
GCLMmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLM mRNA; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]PMID:26365678 PMID:35301059
GCLMincreases expressionISOGclm (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of GCLM mRNAPMID:19010381
GCLMincreases expressionISOGclm (Mus musculus)6480464CTDCadmium Chloride results in increased expression of GCLM mRNAPMID:20061341
GCLMmultiple interactionsISOGclm (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLM mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLM protein; NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLM protein]PMID:26827822 PMID:33398418
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