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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731551
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLMdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of GCLM proteinPMID:25341331
GCLMincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of GCLM mRNAPMID:15725085 PMID:19128835 PMID:19350554 PMID:19417148 PMID:23883479 PMID:25003661 PMID:26705709 PMID:26708503 PMID:27829220
GCLMmultiple interactionsEXP 6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLM mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLM protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of GCLM mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of GCLM mRNA]; Ethionamide inhibits the reaction [Arsenic Trioxide results in increased expression of GCLM mRNA]PMID:19350554 PMID:23883479 PMID:26708503 PMID:33434570
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