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GENE - TERM ANNOTATION REPORT

RGD ID: 731547
Species: Homo sapiens
RGD Object: Gene
Symbol: GRIA1
Name: glutamate ionotropic receptor AMPA type subunit 1
Acc ID: GO:0043197
Term: dendritic spine
Definition: A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
Definition Source(s): GOC:nln
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GRIA1 ISOGria1 (Rattus norvegicus)9068941RGD PMID:12077196 PMID:16338934 PMID:23844251 REF_RGD_ID:1600985 REF_RGD_ID:2312658 REF_RGD_ID:405100729
GRIA1located_inISSUniProtKB:P19490150520179ARUK-UCL GO_REF:0000024
GRIA1located_inIEAUniProtKB:P19490 or UniProtKB:P23818 or ensembl:ENSMUSP00000044494 or ensembl:ENSRNOP00000074119150520179Ensembl GO_REF:0000107
GRIA1is_active_inIBAMGI:95808 or PANTHER:PTN000438081 or Gria2 (Rattus norvegicus) or Gria4 (Rattus norvegicus) or Gria1 (Rattus norvegicus) or Gria3 (Rattus norvegicus) or UniProtKB:P42261150520179GO_Central GO_REF:0000033
GRIA1located_inIEAPANTHER:PTHR18966:SF157150520179TreeGrafter GO_REF:0000118
GRIA1located_inIEAUniProtKB-SubCell:SL-0284150520179UniProt GO_REF:0000044
GRIA1located_inISSUniProtKB:P23818150520179UniProt GO_REF:0000024
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