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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731545
Species: Homo sapiens
RGD Object: Gene
Symbol: PDP1
Name: pyruvate dehydrogenase phosphatase catalytic subunit 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PDP1increases expressionISOPdp1 (Mus musculus)6480464CTDDexamethasone results in increased expression of PDP1 mRNAPMID:22733784
PDP1multiple interactionsISOPdp1 (Rattus norvegicus)6480464CTD[Dexamethasone results in decreased oxidation of Glucose] which results in increased phosphorylation of and results in decreased activity of PDP1 protein; Dexamethasone results in increased phosphorylation of and results in decreased activity of PDP1 protein; INS1 protein inhibits the reaction [Dexamethasone results in increased phosphorylation of PDP1 protein]; Niacinamide inhibits the reaction [Dexamethasone results in increased phosphorylation of PDP1 protein]PMID:20181797
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