Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Estradiol affects the reaction [PTK2B protein affects the expression of GPER1 mRNA]; GPER1 affects the reaction [Estradiol results in increased expression of FOS mRNA]
[Estradiol co-treated with bisphenol A] results in decreased expression of GPER mRNA; GPER1 protein affects the reaction [Estradiol results in decreased expression of HTR1A protein]
2,2',4,4',5-brominated diphenyl ether analog inhibits the reaction [Estradiol analog binds to GPER1 protein]; 2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Estradiol analog binds to GPER1 protein]; 2,2',4,5'-tetrabromodiphenyl ether analog inhibits the reaction [Estradiol analog binds to GPER1 protein]; 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [[GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [[GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; 3-hydroxy-2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [Estradiol analog binds to GPER1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Estradiol analog binds to GPER1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; [Estradiol co-treated with bisphenol A] results in increased expression of GPER1 mRNA; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; [GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein; [GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein; [GPER1 protein results in increased susceptibility to Estradiol] which results in increased phosphorylation of MAPK1 protein; [GPER1 protein results in increased susceptibility to Estradiol] which results in increased phosphorylation of MAPK3 protein; Atrazine inhibits the reaction [Estradiol binds to GPER1 protein]; Estradiol binds to and results in increased activity of GPER1 protein; Estradiol inhibits the reaction [Estradiol analog binds to GPER1 protein]; FR900359 inhibits the reaction [[GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; FR900359 inhibits the reaction [[GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; GPER1 protein affects the reaction [Estradiol affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Estradiol promotes the reaction [CAPN1 protein results in increased cleavage of and results in increased activity of CAPN1 protein]]; GPER1 protein affects the reaction [Estradiol results in increased activity of MMP2 protein]; GPER1 protein affects the reaction [Estradiol results in increased activity of MMP9 protein]; GPER1 protein affects the reaction [Estradiol results in increased expression of FOS protein]; GPER1 protein affects the reaction [Estradiol results in increased expression of MYC mRNA]; GPER1 protein affects the reaction [Estradiol results in increased phosphorylation of EGFR protein]; GPER1 protein affects the reaction [Estradiol results in increased phosphorylation of ELK1 protein]; GPER1 protein affects the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; GPER1 protein affects the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; GPER1 protein affects the reaction [Estradiol results in increased phosphorylation of SRC protein]; GPER1 protein promotes the reaction [Estradiol results in increased expression of CCN2 protein]; GPER1 protein promotes the reaction [Estradiol results in increased expression of ESRRA mRNA]; GPER1 protein promotes the reaction [Estradiol results in increased expression of FOS mRNA]; GPER1 protein promotes the reaction [Estradiol results in increased expression of FOS protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[GPER1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; pentabrominated diphenyl ether 100 analog inhibits the reaction [Estradiol analog binds to GPER1 protein]
