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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731503
Species: Homo sapiens
RGD Object: Gene
Symbol: ROCK2
Name: Rho associated coiled-coil containing protein kinase 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ROCK2increases expressionISORock2 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of ROCK2 proteinPMID:31062909
ROCK2multiple interactionsISORock2 (Rattus norvegicus)6480464CTD[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]PMID:31062909
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