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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731493
Species: Mus musculus
RGD Object: Gene
Symbol: Cdc25a
Name: cell division cycle 25A
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdc25aincreases expressionISOCDC25A (Homo sapiens)6480464CTDEstradiol results in increased expression of CDC25A mRNA; Estradiol results in increased expression of CDC25A proteinPMID:24481588 PMID:24758408 PMID:28880708 PMID:31614463 PMID:9705214
Cdc25amultiple interactionsISOCDC25A (Homo sapiens)6480464CTD[Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK2 protein; [Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK4 protein; sodium arsenite inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA]PMID:24758408 PMID:28880708 PMID:9705214
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