GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp12 | increases cleavage | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased cleavage of CASP12 protein | PMID:27461142 | Casp12 | increases degradation | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased degradation of CASP12 protein | PMID:24157283 | Casp12 | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of CASP12 mRNA; Arsenic Trioxide results in increased expression of CASP12 protein modified form | PMID:23664956 PMID:27638049 PMID:34091186 | Casp12 | multiple interactions | EXP | | 6480464 | CTD | 2-aminoethoxydiphenyl borate inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP12 protein]; 2-aminoethyl diphenylborinate inhibits the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; DDIT3 mutant form inhibits the reaction [Arsenic Trioxide results in increased degradation of CASP12 protein]; HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased degradation of CASP12 protein]; PD 150606 inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP12 protein]; Quin2 inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP12 protein]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form] | PMID:24157283 PMID:27461142 PMID:27638049 | Casp12 | increases cleavage | ISO | CASP12 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased cleavage of CASP12 protein | PMID:19695276 PMID:26110921 | Casp12 | increases cleavage | ISO | Casp12 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased cleavage of CASP12 protein | PMID:21145380 | Casp12 | increases expression | ISO | CASP12 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of CASP12 mRNA | PMID:22959511 | Casp12 | increases expression | ISO | Casp12 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of CASP12 mRNA; Arsenic Trioxide results in increased expression of CASP12 protein modified form | PMID:19730151 PMID:23664956 | Casp12 | multiple interactions | ISO | CASP12 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide promotes the reaction [tetraarsenic tetrasulfide results in increased cleavage of CASP12 protein]; Arsenic Trioxide results in increased expression of and results in increased activity of CASP12 protein; MT2A protein inhibits the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; tetraarsenic tetrasulfide promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP12 protein] | PMID:22959511 PMID:23664956 PMID:26110921 | Casp12 | multiple interactions | ISO | Casp12 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP12 protein] | PMID:21145380 | | ||||||||||||||||||||||
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