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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731381
Species: Mus musculus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis-inducing factor, mitochondrion-associated 1
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1affects localizationISOAifm1 (Rattus norvegicus)6480464CTDHexachlorobenzene affects the localization of AIFM1 proteinPMID:23708402
Aifm1multiple interactionsISOAifm1 (Rattus norvegicus)6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Hexachlorobenzene affects the localization of AIFM1 protein]; Reactive Oxygen Species promotes the reaction [Hexachlorobenzene affects the localization of AIFM1 protein]PMID:23708402
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