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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731324
Species: Homo sapiens
RGD Object: Gene
Symbol: ODC1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ODC1increases activityEXP 6480464CTDRotenone results in increased activity of ODC1 proteinPMID:9834970
ODC1multiple interactionsEXP 6480464CTDRotenone inhibits the reaction [Estradiol results in increased activity of ODC1 protein]; Rotenone inhibits the reaction [IGF1 protein results in increased activity of ODC1 protein]; Rotenone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]PMID:9834970
ODC1decreases expressionISOOdc1 (Mus musculus)6480464CTDRotenone results in decreased expression of ODC1 mRNAPMID:22016648
ODC1increases expressionISOOdc1 (Rattus norvegicus)6480464CTDRotenone results in increased expression of ODC1 mRNAPMID:27900601
ODC1multiple interactionsISOOdc1 (Mus musculus)6480464CTDRotenone analog inhibits the reaction [MYC protein results in increased activity of ODC1 protein]PMID:9270009
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