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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731313
Species: Mus musculus
RGD Object: Gene
Symbol: Pth1r
Name: parathyroid hormone 1 receptor
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pth1rdecreases expressionISOPth1r (Rattus norvegicus)6480464CTDFolic Acid results in decreased expression of PTH1R mRNA; Folic Acid results in decreased expression of PTH1R proteinPMID:11532093 PMID:15728788
Pth1rmultiple interactionsISOPth1r (Rattus norvegicus)6480464CTDEnalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]PMID:15728788
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