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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731297
Species: Homo sapiens
RGD Object: Gene
Symbol: DUSP6
Name: dual specificity phosphatase 6
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DUSP6increases expressionEXP 6480464CTDEstradiol results in increased expression of DUSP6 mRNAPMID:19619570 PMID:30165855 PMID:31614463
DUSP6multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of DUSP6 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP6 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of DUSP6 mRNAPMID:19619570 PMID:20660070 PMID:30165855
DUSP6increases expressionISODusp6 (Rattus norvegicus)6480464CTDEstradiol results in increased expression of DUSP6 mRNAPMID:32145629
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