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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731289
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB1
Name: adrenoceptor beta 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDValproic Acid affects the expression of ADRB1 mRNA

PMID:25979313
increases expressionEXP 6480464CTDValproic Acid results in increased expression of ADRB1 mRNA

PMID:23179753, PMID:24935251, PMID:28001369
increases methylationEXP 6480464CTDValproic Acid results in increased methylation of ADRB1 gene

PMID:29154799
decreases expressionISORGD:20596480464CTDValproic Acid results in decreased expression of ADRB1 protein

PMID:16478526
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.