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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731289
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB1
Name: adrenoceptor beta 1
Acc ID: CHEBI:28918
Term: (R)-adrenaline
Definition: The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
Chemical ID: MESH:D004837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP, Epinephrine binds to and results in increased activity of ADRB1 protein, Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein], Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:14730417, PMID:8096834
multiple interactionsISORGD:101066480464CTD[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine

PMID:12010770
multiple interactionsISORGD:20596480464CTDEpinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:8096834
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.