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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDMethoxychlor binds to PGR protein

PMID:14579009
multiple interactionsEXP 6480464CTDMethoxychlor inhibits the reaction [Progesterone binds to PGR protein]

PMID:14579009
decreases expressionISORGD:110926480464CTDMethoxychlor metabolite results in decreased expression of PGR mRNA

PMID:11509743
decreases expressionISORGD:33176480464CTDMethoxychlor results in decreased expression of PGR mRNA

PMID:16183386, PMID:23303685
increases expressionISORGD:110926480464CTDMethoxychlor results in increased expression of PGR mRNA

PMID:21252393
increases expressionISORGD:33176480464CTDMethoxychlor results in increased expression of PGR mRNA

PMID:10774817, PMID:16183386
multiple interactionsISORGD:110926480464CTD[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of PGR mRNA, [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of PGR mRNA, ESR1 protein inhibits the reaction [Methoxychlor results in increased expression of PGR mRNA]

PMID:11509743, PMID:21252393
multiple interactionsISORGD:33176480464CTD[Methoxychlor co-treated with Genistein] results in increased expression of PGR protein

PMID:11896288
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.