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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGRincreases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of PGR mRNAPMID:18936297 PMID:35307500
PGRmultiple interactionsEXP 6480464CTDEthinyl Estradiol binds to and results in increased activity of PGR proteinPMID:25752796
PGRaffects expressionISOPgr (Rattus norvegicus)6480464CTDEthinyl Estradiol affects the expression of PGR proteinPMID:11218048
PGRdecreases expressionISOPgr (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of PGR mRNAPMID:16551644
PGRincreases expressionISOPgr (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of PGR mRNA; Ethinyl Estradiol results in increased expression of PGR proteinPMID:17574608 PMID:29526645 PMID:30675821
PGRincreases expressionISOPgr (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased expression of PGR mRNA; Ethinyl Estradiol results in increased expression of PGR proteinPMID:10822019 PMID:11218048 PMID:12075121 PMID:12655037 PMID:12834913 PMID:15901920 PMID:16140622 PMID:16183386 PMID:16837883 PMID:19654335
PGRmultiple interactionsISOPgr (Rattus norvegicus)6480464CTD[Ethinyl Estradiol co-treated with Progesterone] results in increased expression of PGR protein; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of PGR protein]; Ursodeoxycholic Acid inhibits the reaction [[Ethinyl Estradiol co-treated with Progesterone] results in increased expression of PGR protein]PMID:14728856 PMID:19654335
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