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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of PGR mRNA, cobaltous chloride results in increased expression of PGR protein

PMID:12746304
multiple interactionsEXP 6480464CTDcobaltous chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA], cobaltous chloride promotes the reaction [Estradiol results in increased expression of PGR protein], Estradiol promotes the reaction [cobaltous chloride results in increased expression of PGR mRNA], Estradiol promotes the reaction [cobaltous chloride results in increased expression of PGR protein], fulvestrant inhibits the reaction [cobaltous chloride results in increased expression of PGR mRNA], fulvestrant inhibits the reaction [cobaltous chloride results in increased expression of PGR protein]

PMID:12746304
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.