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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:34027
Term: 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Definition: A diarylmethane that has formula C14H9Cl5.
Chemical ID: MESH:C016340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDo, p'-DDT binds to PGR protein

PMID:14579009
increases expressionEXP 6480464CTDo, p'-DDT results in increased expression of PGR mRNA

PMID:11867264, PMID:19371625, PMID:20206645, PMID:22609851
multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o, p'-DDT results in increased expression of PGR mRNA], fulvestrant inhibits the reaction [o, p'-DDT results in increased expression of PGR mRNA], o, p'-DDT inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3, 20-dione results in increased activity of PGR protein], o, p'-DDT inhibits the reaction [Progesterone binds to PGR protein], o, p'-DDT inhibits the reaction [Progesterone results in increased expression of PGR protein]

PMID:14579009, PMID:18262749, PMID:20206645, PMID:26022396
decreases expressionISORGD:33176480464CTDo, p'-DDT results in decreased expression of PGR mRNA

PMID:10822019, PMID:23209616
increases expressionISORGD:110926480464CTDo, p'-DDT results in increased expression of PGR mRNA

PMID:9607801
multiple interactionsISORGD:33176480464CTDo, p'-DDT promotes the reaction [Progesterone binds to PGR protein]

PMID:7414049
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.