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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:28428
Term: beta-hexachlorocyclohexane
Definition: The beta-isomer of hexachlorocyclohexane.
Chemical ID: MESH:C023888
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbeta-hexachlorocyclohexane results in increased expression of PGR, beta-hexachlorocyclohexane results in increased expression of PGR mRNA

PMID:16242299, PMID:20206645, PMID:2479123
multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA], beta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3, 20-dione results in increased activity of PGR protein], fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA], ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]

PMID:16242299, PMID:20206645, PMID:26022396
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.