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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGRdecreases expressionEXP 6480464CTDGenistein results in decreased expression of PGR mRNAPMID:20706672
PGRincreases expressionEXP 6480464CTDGenistein results in increased expression of PGR mRNA; Genistein results in increased expression of PGR proteinPMID:10376965 PMID:11368622 PMID:16076101 PMID:19371625 PMID:20884965 PMID:23384675 PMID:23524099 PMID:26865669 PMID:35307500
PGRmultiple interactionsEXP 6480464CTDESR1 protein inhibits the reaction [Genistein results in increased expression of PGR mRNA]; Genistein promotes the reaction [Estradiol results in increased expression of PGR protein]PMID:10376965 PMID:23384675
PGRaffects expressionISOPgr (Rattus norvegicus)6480464CTDGenistein affects the expression of PGR mRNAPMID:23410115
PGRdecreases expressionISOPgr (Mus musculus)6480464CTDGenistein results in decreased expression of PGR mRNAPMID:11880592 PMID:16985261 PMID:21810550
PGRdecreases expressionISOPgr (Rattus norvegicus)6480464CTDGenistein results in decreased expression of PGRPMID:12929590
PGRincreases expressionISOPgr (Mus musculus)6480464CTDGenistein results in increased expression of PGR mRNA; Genistein results in increased expression of PGR proteinPMID:16857750 PMID:18281260 PMID:24365114 PMID:24967385
PGRincreases expressionISOPgr (Rattus norvegicus)6480464CTDGenistein results in increased expression of PGR mRNA; Genistein results in increased expression of PGR protein; Genistein results in increased expression of PGR protein alternative formPMID:10397250 PMID:12075121 PMID:15456929 PMID:15778002 PMID:15901920 PMID:16557470 PMID:20381596 PMID:29217487 PMID:29863768
PGRmultiple interactionsISOPgr (Rattus norvegicus)6480464CTD[Genistein co-treated with vinclozolin] affects the expression of PGR mRNA; [Methoxychlor co-treated with Genistein] results in increased expression of PGR protein; Genistein inhibits the reaction [Estradiol affects the expression of PGR mRNA]PMID:11896288 PMID:17049845 PMID:23410115
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