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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDresveratrol results in decreased activity of PGR protein

PMID:11507064
decreases expressionEXP 6480464CTDresveratrol results in decreased expression of PGR mRNA, resveratrol results in decreased expression of PGR protein

PMID:11606380, PMID:20706672
increases expressionEXP 6480464CTDResveratrol metabolite results in increased expression of PGR mRNA, Resveratrol results in increased expression of PGR mRNA, Resveratrol results in increased expression of PGR protein

PMID:11606380, PMID:19496085, PMID:9391166
multiple interactionsEXP 6480464CTD[resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA], [resveratrol co-treated with pterostilbene] promotes the reaction [Estradiol results in increased expression of PGR mRNA], resveratrol inhibits the reaction [Estradiol results in increased expression of PGR mRNA], resveratrol inhibits the reaction [Estradiol results in increased expression of PGR protein], resveratrol inhibits the reaction [PGR protein affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ITGA1]]

PMID:11507064, PMID:11606380, PMID:11813992, PMID:27159275
decreases expressionISORGD:33176480464CTDresveratrol results in decreased expression of PGR mRNA

PMID:11218048
increases expressionISORGD:33176480464CTDresveratrol results in increased expression of PGR protein

PMID:21248286
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.