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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:2564
Term: aldrin
Definition: An organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with norbornadiene. A proinsecticide (by epoxidation of the non-chlorinated double bond to give dieldrin), it was widely used as an insecticide before being banned in the 1970s as a persistent organic pollutant.
Chemical ID: MESH:D000452
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDAldrin binds to PGR protein

PMID:14579009
multiple interactionsEXP 6480464CTDAldrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3, 20-dione results in increased activity of PGR protein], Aldrin inhibits the reaction [Progesterone binds to PGR protein]

PMID:14579009, PMID:26022396
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.