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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:132098
Term: methoxyacetic acid
Definition: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group.
Chemical ID: MESH:C013598
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGRmultiple interactionsEXP 6480464CTDmethoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]; Mifepristone inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]PMID:15103026 PMID:18486176
PGRincreases expressionISOPgr (Rattus norvegicus)6480464CTDmethoxyacetic acid results in increased expression of PGR mRNAPMID:20864626
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