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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731079
Species: Homo sapiens
RGD Object: Gene
Symbol: GRIN2B
Name: glutamate ionotropic receptor NMDA type subunit 2B
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GRIN2Baffects expressionISOGrin2b (Rattus norvegicus)6480464CTDCocaine affects the expression of GRIN2B mRNA; Cocaine affects the expression of GRIN2B proteinPMID:11032893 PMID:15140200 PMID:19105975 PMID:20187946
GRIN2Baffects response to substanceISOGrin2b (Rattus norvegicus)6480464CTDGRIN2B protein affects the susceptibility to CocainePMID:11801363
GRIN2Bdecreases phosphorylationISOGrin2b (Rattus norvegicus)6480464CTDCocaine results in decreased phosphorylation of GRIN2B proteinPMID:16794574
GRIN2Bincreases expressionISOGrin2b (Rattus norvegicus)6480464CTDCocaine results in increased expression of GRIN2B proteinPMID:11801363 PMID:16794574 PMID:19306440 PMID:19474322
GRIN2Bmultiple interactionsISOGrin2b (Rattus norvegicus)6480464CTDDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in decreased phosphorylation of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]PMID:11801363 PMID:16794574 PMID:19474322
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