GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | decreases expression | EXP | | 6480464 | CTD | Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein | PMID:17440100 PMID:19297423 PMID:21397623 | Vegfa | multiple interactions | EXP | | 6480464 | CTD | [Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein; Curcumin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA] | PMID:17440100 PMID:19297423 | Vegfa | affects expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Curcumin affects the expression of VEGFA mRNA | PMID:17960570 | Vegfa | decreases expression | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein | PMID:18497527 | Vegfa | decreases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein | PMID:18226269 PMID:18390174 PMID:18593936 PMID:19294764 PMID:19372569 PMID:19383353 | Vegfa | multiple interactions | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] | PMID:17662242 PMID:23845850 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin co-treated with Bortezomib] results in decreased expression of VEGFA protein; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin results in decreased expression of and results in decreased secretion of VEGFA protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein] | PMID:16219905 PMID:16243823 PMID:16368150 PMID:18226269 PMID:18596194 PMID:19372569 PMID:20554536 PMID:23555722 PMID:25447407 PMID:35752269 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |