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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731073
Species: Mus musculus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:28527
Term: rutin
Definition: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.
Chemical ID: MESH:D012431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDRutin results in decreased expression of VEGFA mRNAPMID:20015448
Vegfamultiple interactionsISOVegfa (Rattus norvegicus)6480464CTDRutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]PMID:33413359
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDRutin results in decreased secretion of and results in decreased expression of VEGFA protein; Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA]; Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA]; Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein]PMID:20015448
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