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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731073
Species: Mus musculus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:178564
Term: Auriculasin
Definition: null
Chemical ID: MESH:C516713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDauriculasin results in decreased expression of VEGFA proteinPMID:30236598
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDauriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]PMID:30236598
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