GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | VEGFA | decreases expression | EXP | | 6480464 | CTD | Simvastatin results in decreased expression of VEGFA protein | PMID:16424782 | VEGFA | increases expression | EXP | | 6480464 | CTD | Simvastatin results in increased expression of VEGFA; Simvastatin results in increased expression of VEGFA mRNA | PMID:18356691 PMID:20381859 | VEGFA | increases secretion | EXP | | 6480464 | CTD | Simvastatin results in increased secretion of VEGFA protein | PMID:18356691 | VEGFA | multiple interactions | EXP | | 6480464 | CTD | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; HIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of VEGFA protein] | PMID:16424782 PMID:17277159 PMID:18356691 | VEGFA | increases expression | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Simvastatin results in increased expression of VEGFA mRNA; Simvastatin results in increased expression of VEGFA protein | PMID:20687301 PMID:21211366 | VEGFA | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Simvastatin results in increased expression of VEGFA mRNA; Simvastatin results in increased expression of VEGFA protein | PMID:15572054 PMID:18316203 | VEGFA | multiple interactions | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Simvastatin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] | PMID:18569938 PMID:20821229 | | ||||||||||||||||||||||
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