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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAdecreases expressionEXP 6480464CTDdiallyl trisulfide results in decreased expression of VEGFA mRNA; diallyl trisulfide results in decreased expression of VEGFA proteinPMID:23430952 PMID:23754639 PMID:28574600
VEGFAmultiple interactionsEXP 6480464CTDdiallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; diallyl trisulfide results in decreased expression of and results in decreased secretion of VEGFA protein; NOTCH1 mutant form promotes the reaction [diallyl trisulfide results in decreased secretion of VEGFA protein]PMID:23430952 PMID:28574600
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