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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:4653
Term: dipyridamole
Definition: A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Chemical ID: MESH:D004176
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAincreases secretionEXP 6480464CTDDipyridamole results in increased secretion of VEGFA proteinPMID:20067761
VEGFAmultiple interactionsEXP 6480464CTDAdenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]PMID:20067761
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