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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAincreases expressionEXP 6480464CTDAcrolein results in increased expression of VEGFA proteinPMID:22928487
VEGFAmultiple interactionsEXP 6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of VEGFA mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of VEGFA mRNA; cesium chloride inhibits the reaction [Acrolein results in increased expression of VEGFA protein]; Rotenone inhibits the reaction [Acrolein results in increased expression of VEGFA protein]PMID:22928487 PMID:32699268
VEGFAincreases expressionISOVegfa (Mus musculus)6480464CTDAcrolein results in increased expression of VEGFA proteinPMID:30608172
VEGFAmultiple interactionsISOVegfa (Mus musculus)6480464CTD[Ovalbumin co-treated with Acrolein] results in increased expression of VEGFA proteinPMID:30608172
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