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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRincreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AHR mRNAPMID:31326446
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]PMID:16601081
AHRmultiple interactionsISOAhr (Rattus norvegicus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog binds to and results in increased activity of AHR protein; 2,2',4,4'-tetrabromodiphenyl ether binds to and results in decreased activity of AHR protein; 2,2',4,4'-tetrabromodiphenyl ether binds to and results in increased activity of AHR protein; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]PMID:12850102 PMID:16601080 PMID:16601081
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