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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:43355
Term: indoxyl sulfate
Definition: An aryl sulfate that is indoxyl in which the hydroxyl hydrogen is substituted by a sulfo group.
Chemical ID: MESH:D007200
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRincreases expression EXP 401793752RGDindoxyl sulfate increases expression of mRNA, protein in HK-2 human kidney proximal tubule cell line 
AHRaffects localizationISOAhr (Rattus norvegicus)401793746RGDindoxyl sulfate affects localization in rat cultured cardiomyocyte cells 
AHRincreases bindingISOAhr (Rattus norvegicus)401793746RGDindoxyl sulfate increases DNA promoter binding in rat cultured cardiomyocyte cells 
AHRincreases expression ISOAhr (Rattus norvegicus)401793752RGDindoxyl sulfate increases expression of protein in rat kidney 
AHRincreases expression ISOAhr (Rattus norvegicus) or Ahr (Mus musculus)401793746RGDindoxyl sulfate increases expression of mRNA, protein in rat cultured cardiomyocyte cells and mouse heart 
AHRincreases expressionEXP 6480464CTDIndican results in increased expression of AHR mRNAPMID:21493753
AHRmultiple interactionsEXP 6480464CTDFlavones inhibits the reaction [Indican results in increased activity of AHR protein]; Indican binds to and results in increased activity of AHR protein; N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Indican results in increased expression of AHR mRNA]PMID:20000589 PMID:21493753
AHRincreases activityISOAhr (Mus musculus)6480464CTDIndican results in increased activity of AHR proteinPMID:20000589 PMID:23639249
AHRincreases expressionISOAhr (Mus musculus)6480464CTDIndican results in increased expression of AHR mRNAPMID:23639249
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTDIndican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]PMID:26259605
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