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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:36419
Term: 4,7-phenanthroline
Definition: A phenanthroline that has formula C12H8N2.
Chemical ID: MESH:C053487
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRdecreases activityEXP 6480464CTD4,7-phenanthroline results in decreased activity of AHR proteinPMID:8738555
AHRmultiple interactionsEXP 6480464CTD4,7-phenanthroline inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]PMID:8738555
AHRmultiple interactionsISOAhr (Rattus norvegicus)6480464CTD4,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 4,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]PMID:1322109
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