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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRaffects localizationEXP 6480464CTDOzone affects the localization of AHR proteinPMID:19536146
AHRincreases expressionEXP 6480464CTDOzone results in increased expression of AHR mRNAPMID:19536146
AHRmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [Ozone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Ozone results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [Ozone results in increased expression of CYP1A2 mRNA]; AHR protein affects the reaction [Ozone results in increased expression of CYP1A2 protein]; AHR protein affects the reaction [Ozone results in increased expression of CYP1B1 mRNA]; AHR protein affects the reaction [Ozone results in increased expression of CYP1B1 protein]; AHR protein affects the reaction [Ozone results in increased phosphorylation of EGFR protein]PMID:19536146
AHRdecreases expressionISOAhr (Mus musculus)6480464CTDOzone results in decreased expression of AHR mRNAPMID:12763052
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of AHR mRNAPMID:34911549
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