GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AHR | decreases expression | EXP | | 6480464 | CTD | Tretinoin results in decreased expression of AHR mRNA | PMID:23724009 | AHR | increases expression | EXP | | 6480464 | CTD | Tretinoin results in increased expression of AHR mRNA | PMID:16480812 PMID:21934132 PMID:33167477 | AHR | multiple interactions | EXP | | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Tretinoin] results in decreased expression of AHR mRNA; AHR protein promotes the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]] | PMID:15075337 | AHR | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | [ALDH1A3 results in increased chemical synthesis of Tretinoin] which results in increased expression of AHR; [Tretinoin co-treated with Cycloheximide] results in increased expression of AHR mRNA; AHR protein promotes the reaction [CYP2C39 protein results in increased hydroxylation of Tretinoin]; Tretinoin affects the reaction [ALDH1A3 affects the expression of AHR] | PMID:14623888 PMID:21807577 | AHR | multiple interactions | ISO | Ahr (Rattus norvegicus) | 6480464 | CTD | AHR protein promotes the reaction [CYP2C6V1 protein results in increased hydroxylation of Tretinoin] | PMID:14623888 | | ||||||||||||||||||||||
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