GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rhoa | multiple interactions | EXP | | 6480464 | CTD | farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein] | PMID:18310456 | Rhoa | affects localization | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Simvastatin affects the localization of RHOA protein | PMID:16740276 PMID:18625202 PMID:20045437 | Rhoa | decreases activity | ISO | Rhoa (Rattus norvegicus) | 6480464 | CTD | Simvastatin results in decreased activity of RHOA protein | PMID:21124329 | Rhoa | decreases expression | ISO | Rhoa (Rattus norvegicus) | 6480464 | CTD | Simvastatin results in decreased expression of RHOA; Simvastatin results in decreased expression of RHOA protein | PMID:16698853 PMID:19659652 | Rhoa | decreases prenylation | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased prenylation of RHOA protein | PMID:16005304 PMID:21257924 | Rhoa | increases expression | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased expression of RHOA mRNA | PMID:14630613 | Rhoa | increases expression | ISO | Rhoa (Rattus norvegicus) | 6480464 | CTD | Simvastatin results in increased expression of RHOA protein | PMID:15200425 | Rhoa | increases localization | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased localization of RHOA protein | PMID:16005304 | Rhoa | multiple interactions | ISO | RHOA (Homo sapiens) | 6480464 | CTD | farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; RHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; Simvastatin affects the localization of and results in decreased activity of RHOA protein; Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]; Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]; Simvastatin results in decreased localization of and results in decreased activity of RHOA protein; Simvastatin results in increased localization of and results in decreased prenylation of RHOA protein | PMID:12477733 PMID:16005304 PMID:16470222 PMID:17075836 PMID:17560598 PMID:18031796 PMID:18463201 PMID:18625202 PMID:18625914 PMID:18981156 | Rhoa | multiple interactions | ISO | Rhoa (Rattus norvegicus) | 6480464 | CTD | geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of RHOA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; Simvastatin results in decreased geranoylation of and results in decreased prenylation of RHOA protein | PMID:15200425 PMID:16698853 PMID:19024099 PMID:24449418 | | ||||||||||||||||||||||
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