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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731055
Species: Mus musculus
RGD Object: Gene
Symbol: Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Acc ID: CHEBI:22633
Term: arsenite ion
Definition: An arsenic oxoanion resulting from the removal of one or more protons from arsenous acid.
Chemical ID: MESH:D018053
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx2increases expressionEXP 6480464CTDArsenites results in increased expression of EPHX2 mRNAPMID:22680237
Ephx2multiple interactionsEXP 6480464CTD[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid; [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of 11,12-dihydroxyeicosatrienoic acid; [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of 14,15-dihydroxyeicosatrienoic acid; [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of eicosa-5,11,14-trienoic acid analog; Arsenites results in increased expression of and results in increased activity of EPHX2 proteinPMID:22680237
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