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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731027
Species: Homo sapiens
RGD Object: Gene
Symbol: BDNF
Name: brain derived neurotrophic factor
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BDNFincreases expression ISOBdnf (Rattus norvegicus)401959617RGDMorphine increases expression of Bdnf mRNA in ventral tegmental area  
BDNFdecreases expressionISOBdnf (Mus musculus)6480464CTDMorphine results in decreased expression of BDNF mRNAPMID:25643298
BDNFdecreases expressionISOBdnf (Rattus norvegicus)6480464CTDMorphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative formPMID:25643298
BDNFincreases expressionISOBdnf (Mus musculus)6480464CTDMorphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF proteinPMID:19033880 PMID:27461790
BDNFmultiple interactionsISOBdnf (Mus musculus)6480464CTDAM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]PMID:19033880 PMID:25643298 PMID:27461790
BDNFmultiple interactionsISOBdnf (Rattus norvegicus)6480464CTDMorphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]PMID:25643298
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