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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731027
Species: Homo sapiens
RGD Object: Gene
Symbol: BDNF
Name: brain derived neurotrophic factor
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BDNFaffects expressionISOBdnf (Rattus norvegicus)6480464CTDCorticosterone affects the expression of BDNF proteinPMID:32733244
BDNFdecreases expressionISOBdnf (Mus musculus)6480464CTDCorticosterone results in decreased expression of BDNF proteinPMID:22850435
BDNFdecreases expressionISOBdnf (Rattus norvegicus)6480464CTDCorticosterone results in decreased expression of BDNF mRNAPMID:22244747 PMID:27988398
BDNFmultiple interactionsISOBdnf (Mus musculus)6480464CTD2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]; KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]PMID:22850435
BDNFmultiple interactionsISOBdnf (Rattus norvegicus)6480464CTDO-1602 compound affects the reaction [Corticosterone affects the expression of BDNF protein]; so-ochim-tang-gamibang inhibits the reaction [Corticosterone results in decreased expression of BDNF mRNA]PMID:27988398 PMID:32733244
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